There is an Ayat in the Quran where due to hadiths, it has completely missed its purpose;
The ayat is 3:61

3:61

If anyone disputes with you regarding Jesus; after the correct knowledge has come to you, say, "Come! We will advise our families and followers and your families and followers, and ourselves and yourselves to maintain our respective beliefs and leave one another alone. Rejection of the Divine Truth deprives people of Allah's Grace."

I was told without hadith,  there is no way I could interpret the meaning behind this Ayat.

The common understanding of this (due to hadiths) is "Event of Mubahala"

(as portrayed in the movie "The Message") and the hadith can be found in

Muslim 31:5915 ( http://hadith.islamicevents.sg/muslim/hadith/31/5915 )

According to hadiths the prophet was debating Christians scholars and said this Ayat as a challenge.
Once the challenge was accepted by the Christians, they saw the prophet attended with his Ahlul-Bayt (Ali, Fatima, Hassan, Hussein) and as they sat under a tree, the Christians realised he was truly a prophet of Allah.

Now let me show you the truth of what the Ayat means and it has nothing to do with Muhammad or Ahlul Bayt.
 

I will show by his permission this Ayat is words that the angel said to Mariyam upon his visit to her and is a revelation to Mariyam about her son and future events.

 

For understanding purposes, however, we need to start from a lot further up the Surah and work our way down to the Ayat in question

 

[3:46-47]

When said the Angels, "O Maryam! Indeed, Allah gives you glad tidings of a word from Him, his name (is) the Messiah, Isa, son (of) Maryam, honored in the world and (in) the Hereafter, and of those brought near (to Allah). And he will speak (to) the people in the cradle and (in) maturity; and (he will be) of the righteous."

 

[3:48]

She said, "My Lord how is [it] for me a boy, and (has) not touch(ed) me any man?" He said, "Thus Allah creates what He wills. When He decrees a matter then only He says to it, "Be," and it becomes.

 

3:46-47 are the direct words spoken to Maryam from the angel and 3:48 is Maryam's response

 

Then the angel (well-made man) starts responding to Mary and he explains what Jesus will say, do and face in the future.

 

[3:49-51]

And He will teach him the Book, and [the] wisdom, and the Taurat, and the Injeel. And (make him) a Messenger to (the) Children (of) Israel, "Indeed, I [surely] [I] (have) come (to) you with a sign from your Lord that I [I] design for you from [the] clay like the form (of) the bird, then I breath into it and it becomes a bird by (the) permission (of) Allah. And I cure the blind, and the leper, and I give life (to) the dead by (the) permission (of) Allah. And I inform you of what you eat and what you store in your houses. Indeed, in that (is) surely a sign for you, if you are believers. And confirming that which (was) before me of the Taurat, and so that I make lawful for you some (of) that which was forbidden to you. And I (have) come to you with a sign from your Lord. So fear Allah and obey me. Indeed, Allah (is) my Lord and your Lord, so worship Him. This (is) the straight path."

 

From 3:49 to 3:51 the angel tells Maryam what Jesus will say.

This means these are not only the words that Jesus did say, but this is actually a revelation to Maryam about what her son will say (at this point in time Jesus hadn't said it, he wasn't even born yet so the angel is only describing what he will say in future.)

 

[3:52]

Then when perceived Isa from them [the] disbelief he said, "Who (will be) my helpers to Allah." Said the disciples "We (will be the) helpers (of) Allah, we believe[d] in Allah and bear witness that we (are) Muslims.

 

In 3:52 the first words are,

Falamma ahssa Isa min'hummu l-kuf'ra qala....

Literally translation 

"Then when perceived from them disbelief he said"

 

So now Maryam is being told about her sons' emotional distress and his response to the disciples. 

Again it is vital to understand Jesus hasn't actually said any of this yet merely it is being told to Mariyam what he will say.

 

[3:53]

Our Lord, we believe[d] in what You revealed and we follow[ed] the Messenger, then write us among the witnesses."

 

[3:54]

And they schemed, and Allah planned. And Allah (is the) best (of) the planners.

 

3.53 is telling Maryam about the response his disciples will give and 

3.54 explains to Maryam how they planned but Allah is the best of planners. The angel telling Maryam about Allah being the best of planners is to reassure Maryam her son will be safe when the disciple(s) do plan against him.

 

[3:55-57]

When Allah said "O Isa! Indeed, I (will) take you and raise you to Myself and purify you from those who disbelieve[d], and I will make those who follow[ed] you superior (to) those who disbelieve[d] on (the) Day (of) [the] Resurrection. Then to Me (is) your return and I will judge between you about what you were [in it] differing. Then as for those who disbelieve[d], then I will punish them (with) a punishment severe in the world and (in) the Hereafter. And not for them any helpers. And as for those who believe[d] and did [the] righteous deeds then He will grant them in full their reward. And Allah (does) not love the wrongdoers.

 

3:55-57 is telling Maryiam her sons life and what Allah will say to him in future when the disciple situation arises.

 

[3:58]

 That (is what) We recite [it] to you of the Verses and the Reminder - [the] Wise.

 

The "You" mentioned in 3:58 is directed to Mariyam. This ayat is confirming her receiving the revelations.

 

[3:59]

Indeed, (the) likeness (of) Isa near Allah (is) like (the) likeness (of) Adam. He created him from dust then He said to him, "Be," and he was.

 

In 3:59 the angel explains to Mariyam how Jesus is like Adam and giving a bit more detail to what she was told before, Be and it is.

 

[3:60]

The truth (is) from your Lord, so (do) not be among the doubters.

 

Then in 3:60 the angel then confirms with Mariyam it is the truth and reassures her not to be of the doubters (about her pregnancy and Be and it is)

 

So now to Ayat in question 3:61 

 

[3:61]

Then whoever argues (with) you concerning it after what came to you of the knowledge then say, "Come, let us call our sons and your sons, and our women and your women, and ourselves and yourselves, then let us pray humbly, and [we] invoke the curse (of) Allah on the liars. 

 

This is Ayat has nothing to do with Muhammad or Ahlul Bayt.

It is a revelation to Maryam and the response Maryam should give when they dispute her concerning her virgin birth and her son.

The ayat has a masculine emphasis but Maryiam is given a masculine position (I.e Isa son of Mariyam)

 

[3:62-63]

Indeed this, surely it (is) the narration - [the] true. And (there is) no god except Allah. And indeed, Allah, surely He (is) the All-Mighty, the All-Wise. And if they turn back, then indeed, Allah (is) All-Knowing, of the corrupters.

 

Finally 3:62-63 is the angel confirming whatever she has been told in regards to her pregnancy and her future sons' ordeals are the truth

 

So just to reiterate, the whole thing from 3:46-63 is a revelation to Maryam.

The angel just didn't impregnate her and leave her on her own accord to defend herself,

he explained in detail what will occur and how to respond when it does.

​